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KMID : 1024519970060020189
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Journal of the Environmental Sciences
1997 Volume.6 No. 2 p.189 ~ p.194
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Bioenvironmental Interaction of Toxic Peptide Hornet Venom with Phospholipid
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Kim Kwang-Ho
Lee Bong-Hun
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Abstract
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Toxic peptides from hornet venom, mastoparan and mastoparan-B were synthesized us- ing the solid phase peptide synthesis method and investigated the interaction of them with phospholipid bilayer, antibacterial activity, and hemolytic activity. Both toxic peptides could induce dye release at a low concentration in neutral liposome. The binding affinity of mastoparan-B for neutral liposome was smaller than that for acidic one. Mastoparan and mastoparan-B had strong antibacterial activity for gram-positive bacteria, but weak or potent activity for gram-negative ones, respectively. Mastoparan and mastoparan-B lysed erythrocyte very little up to 5 M.
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KEYWORD
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toxic peptide, hornet venom, phospholipid
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